Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture
The stiffness of biological membranes determines the work required by cellular machinery to
form and dismantle vesicles and other lipidic shapes. Model membrane stiffness can be …
form and dismantle vesicles and other lipidic shapes. Model membrane stiffness can be …
Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction
Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …
Physiological changes in bilayer thickness induced by cholesterol control GPCR rhodopsin function
O Soubias, AJ Sodt, WE Teague, KG Hines… - Biophysical …, 2023 - cell.com
We monitored the effect on function of the G-protein-coupled receptor (GPCR) rhodopsin
from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of …
from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of …
Softening in two-component lipid mixtures by spontaneous curvature variance
The bending modulus of a lipid bilayer quantifies its mechanical resistance to curvature. It is
typically understood in terms of thickness; eg, thicker bilayers are usually stiffer. Here, we …
typically understood in terms of thickness; eg, thicker bilayers are usually stiffer. Here, we …
Molecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures
Membrane reshaping is an essential biological process. The chemical composition of lipid
membranes determines their mechanical properties and thus the energetics of their shape …
membranes determines their mechanical properties and thus the energetics of their shape …
Curvature-based sorting of eight lipid types in asymmetric buckled plasma membrane models
EA Cino, DP Tieleman - Biophysical Journal, 2022 - cell.com
Curvature is a fundamental property of biological membranes and has essential roles in
cellular function. Bending of membranes can be induced by their lipid and protein …
cellular function. Bending of membranes can be induced by their lipid and protein …
Lipid redistribution in the highly curved footprint of Piezo1
We investigate the effects on the distribution of lipids in the plasma membrane that are
caused by the insertion of a protein, Piezo1, that significantly distorts the membrane toward …
caused by the insertion of a protein, Piezo1, that significantly distorts the membrane toward …
[PDF][PDF] MembraneAnalysis. jl: A Julia package for analyzing molecular dynamics simulations of lipid membranes
Biological membranes separate living cells from their surroundings, and, in case of
eukaryotes, partition the cell into its constituent organelles. These bilayer structures, which …
eukaryotes, partition the cell into its constituent organelles. These bilayer structures, which …
Origin of the nonlinear structural and mechanical properties in oppositely curved lipid mixtures
Structural and mechanical properties of membranes such as thickness, tail order, bending
modulus and curvature energetics play crucial role in controlling various cellular functions …
modulus and curvature energetics play crucial role in controlling various cellular functions …
Systematic analysis of curvature-dependent lipid dynamics in a stochastic 3D membrane model
To minimize the free energy of the system, lipid membranes display curvature-dependent
rearrangements at the local and global scale. The optimal membrane shape is generally …
rearrangements at the local and global scale. The optimal membrane shape is generally …