International union of basic and clinical pharmacology. C. Nomenclature and properties of calcium-activated and sodium-activated potassium channels

LK Kaczmarek, RW Aldrich, KG Chandy… - Pharmacological …, 2017 - ASPET
A subset of potassium channels is regulated primarily by changes in the cytoplasmic
concentration of ions, including calcium, sodium, chloride, and protons. The eight members …

The Slo (w) path to identifying the mitochondrial channels responsible for ischemic protection

CO Smith, K Nehrke, PS Brookes - Biochemical Journal, 2017 - portlandpress.com
Mitochondria play an important role in tissue ischemia and reperfusion (IR) injury, with
energetic failure and the opening of the mitochondrial permeability transition pore being the …

Structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB

WT Chiang, YK Chang, WH Hui, SW Chang… - Nature …, 2024 - nature.com
The K+ uptake system KtrAB is essential for bacterial survival in low K+ environments. The
activity of KtrAB is regulated by nucleotides and Na+. Previous studies proposed a putative …

The epilepsy of infancy with migrating focal seizures: identification of de novo mutations of the KCNT2 gene that exert inhibitory effects on the corresponding …

X Mao, N Bruneau, Q Gao, H Becq, Z Jia… - Frontiers in Cellular …, 2020 - frontiersin.org
The epilepsy of infancy with migrating focal seizures (EIMFS; previously called Malignant
migrating partial seizures of infancy) are early-onset epileptic encephalopathies (EOEE) that …

Identification of the intracellular Na+ sensor in Slo2. 1 potassium channels

SJ Thomson, A Hansen, MC Sanguinetti - Journal of Biological Chemistry, 2015 - ASBMB
Slo2 potassium channels have a very low open probability under normal physiological
conditions, but are readily activated in response to an elevated [Na+] i (eg during ischemia) …

Transcriptional regulation of the sodium-activated potassium channel SLICK (KCNT2) promoter by nuclear factor-κB

DL Tomasello, AM Gancarz-Kausch, DM Dietz… - Journal of Biological …, 2015 - ASBMB
Although recent studies have shown the sodium-activated potassium channel SLACK
(KCNT1) can contribute to neuronal excitability, there remains little information on the …

[HTML][HTML] Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2. 1 potassium channels

T Suzuki, A Hansen, MC Sanguinetti - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Under normal physiological conditions, Slo2. 1 K+ channels are in a closed state unless
activated by an elevation in [Na+] i. Fenamates such as niflumic acid also activate Slo2. 1 …

Dynamic heterogeneity and non-Gaussian statistics for ganglioside GM1s and acetylcholine receptors on live cell membrane

W He, Y Su, HB Peng, P Tong - Molecular Biology of the Cell, 2020 - Am Soc Cell Biol
We have carried out a comparative study of the lateral motion of ganglioside GM1, which is a
glycosphingolipid residing on the outer leaflet of the plasma membrane, and acetylcholine …

[PDF][PDF] Natrium-abhängige Kaliumkanäle im sensorischen System

C Flauaus - 2022 - d-nb.info
Empfindung Schmerz als „unangenehme sensorische und gefühlsmäßige Erfahrung, die mit
einer tatsächlichen oder potenziellen Gewebeschädigung einhergeht oder dieser ähnelt< …

[PDF][PDF] of KCNT2 in EOEE and provide novel insights into the role of heteromeric KNa channel in the severe KCNT2-related epileptic phenotypes. This may have …

X Mao, N Bruneau, Q Gao, H Becq, Z Jia, H Xi, L Shu… - archive.jibiology.com
The epilepsy of infancy with migrating focal seizures (EIMFS; previously called Malignant
migrating partial seizures of infancy) are early-onset epileptic encephalopathies (EOEE) that …