Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …

There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …

The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …

Gender bias and the role of sex hormones in autoimmune diseases are well established. In
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …

In addition to the secretion of Ag-specific Abs, B cells may play an important role in the
generation of immune responses by efficiently presenting Ag to T cells. We and other …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder that affects an estimated 30
million people worldwide. It is characterized by the destruction of pancreatic β cells by the …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …

NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an …