Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review
DG Lynch, RK Narayan, C Li - Journal of Clinical Medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …
extensive research efforts, the majority of trialed monotherapies to date have failed to …
[HTML][HTML] Very delayed remote ischemic post-conditioning induces sustained neurological recovery by mechanisms involving enhanced angioneurogenesis and …
TR Doeppner, B Zechmeister, B Kaltwasser… - Frontiers in Cellular …, 2018 - frontiersin.org
Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated
in an experimental paradigm that involves a stimulus of injurious ischemia, activating …
in an experimental paradigm that involves a stimulus of injurious ischemia, activating …
Delayed CO2 postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression
Y Li, R Chen, GP Shen, J Yin, Y Li… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Few treatments are available in the subacute phase of traumatic brain injury (TBI)
except rehabilitation training. We previously reported that transient CO2 inhalation applied …
except rehabilitation training. We previously reported that transient CO2 inhalation applied …
Remote ischemic conditioning reduced acute lung injury after traumatic brain injury in the mouse
M Saber, AD Rice, I Christie, RG Roberts, KS Knox… - Shock, 2021 - journals.lww.com
Traumatic brain injury (TBI) can induce acute lung injury (ALI). The exact pathomechanism
of TBI-induced ALI is poorly understood, limiting treatment options. Remote ischemic …
of TBI-induced ALI is poorly understood, limiting treatment options. Remote ischemic …
[HTML][HTML] Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury
RP Bruhns, MI Sulaiman, M Gaub, EH Bae… - Frontiers in Behavioral …, 2022 - frontiersin.org
Introduction: Traumatic brain injury (mTBI) is a leading cause of disability in the US.
Angiotensin 1-7, an endogenous peptide, acts at MAS receptors to inhibit inflammatory …
Angiotensin 1-7, an endogenous peptide, acts at MAS receptors to inhibit inflammatory …
The impact of serial remote ischemic conditioning on dynamic cerebral autoregulation and brain injury related biomarkers
Y Qu, P Zhang, QY He, YY Sun, MQ Wang… - Frontiers in …, 2022 - frontiersin.org
Objective Recent studies have demonstrated the positive roles of remote ischemic
conditioning (RIC) in patients with cerebrovascular diseases; however, the mechanisms …
conditioning (RIC) in patients with cerebrovascular diseases; however, the mechanisms …
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI
KE Singer, TE Wallen, MC Morris… - Journal of Trauma …, 2021 - journals.lww.com
BACKGROUND Traumatic brain injury (TBI) is common in civilians and military personnel.
No potential therapeutics have been evaluated to prevent secondary injury induced by the …
No potential therapeutics have been evaluated to prevent secondary injury induced by the …
Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury
BACKGROUND β-blockers have been shown to improve survival after traumatic brain injury
(TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not …
(TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not …
Remote ischemic conditioning in emergency medicine—clinical frontiers and research opportunities
Time-critical acute ischemic conditions such as ST-elevation myocardial infarction and acute
ischemic stroke are staples in Emergency Medicine practice. While timely reperfusion …
ischemic stroke are staples in Emergency Medicine practice. While timely reperfusion …