The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Extracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are
released by nearly all cell types and carry a cargo of proteins and nucleic acids that varies …

Background: Extracellular vesicles (EVs) are a heterogeneous class of lipid bound particles
shed by any cell in the body in physiological and pathological conditions. EVs play critical …

BACKGROUND. Right-sided heart failure is the leading cause of death in pulmonary arterial
hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β …

Both physiological homeostasis and pathological disease processes in the lung typically
result from complex, yet coordinated multicellular responses that are synchronized via …

Intact cell-free mitochondria have been reported in microparticles (MPs) in murine and
human bodily fluids under disease conditions. However, cellular origins of circulating …

Pulmonary arterial hypertension (PAH), also known as Group 1 Pulmonary Hypertension
(PH), is a PH subset characterized by pulmonary vascular remodeling and pulmonary …

Simple Summary This review discusses the role of extracellular vesicles in pulmonary
hypertension a serious and progressive lung disease characterized by high blood pressure …

Extracellular vesicles (EVs) are highly abundant in human biofluids, containing a repertoire
of macromolecules and biomarkers representative of the tissue of origin. EVs released by …

Pulmonary arterial hypertension (PAH) is a severe medical condition characterized by
elevated pulmonary vascular resistance (PVR), right ventricular (RV) failure, and death in …