Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC),
ranks the fourth leading cause of cancer-related deaths in the western world. While the …

High mortality and morbidity rates and variable clinical behavior are hallmarks of
glioblastoma (GBM), the most common and aggressive primary malignant brain tumor …

Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

Cholangiocarcinoma (CCA), the second most frequent liver cancer after hepatocellular
carcinoma, has been rising worldwide in recent epidemiological research. This neoplasia's …

Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Therapy resistance is a major problem when treating cancer patients as cancer cells
develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …