Methods to induce targeted protein degradation through bifunctional molecules

J Bradner, D Buckley, G Winter - US Patent 9,821,068, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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IRAK degraders and uses thereof

N Mainolfi, N Ji, AF Kluge, MM Weiss… - US Patent 10,874,743, 2020 - Google Patents
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Regulated biocircuit systems

P Barrett, MN Gladstone, TA Kassum, V Suri… - US Patent …, 2022 - Google Patents
US11446398B2 - Regulated biocircuit systems - Google Patents US11446398B2 -
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Tricyclic CRBN ligands and uses thereof

N Ji, AF Kluge, MM Weiss, Y Zhang - US Patent 11,292,792, 2022 - Google Patents
US11292792B2 - Tricyclic CRBN ligands and uses thereof - Google Patents
US11292792B2 - Tricyclic CRBN ligands and uses thereof - Google Patents Tricyclic CRBN …

Targeted protein degradation using a mutant E3 ubiquitin ligase

J Bradner, M Ishoey, D Buckley, J Paulk… - US Patent …, 2019 - Google Patents
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Protein degraders and uses thereof

N Mainolfi, N Ji, AF Kluge - US Patent 11,485,743, 2022 - Google Patents
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CRBN ligands and uses thereof

N Mainolfi, N Ji, AF Kluge - US Patent 11,512,080, 2022 - Google Patents
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IRAK degraders and uses thereof

N Mainolfi, N Ji, AF Kluge, MM Weiss, Y Zhang… - US Patent …, 2022 - Google Patents
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IRAK degraders and uses thereof

N Mainolfi, N Ji, AF Kluge, MM Weiss, Y Zhang… - US Patent …, 2021 - Google Patents
2020-09-22 Assigned to KYMERA THERAPEUTICS, INC. reassignment KYMERA
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IRAK degraders and uses thereof

MM Weiss - US Patent 11,779,578, 2023 - Google Patents
A61K47/50—Medicinal preparations characterised by the non-active ingredients used, eg
carriers or inert additives; Targeting or modifying agents chemically bound to the active …