Cerebral oxygen extraction fraction MRI: Techniques and applications
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …
Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults
We aimed to validate oxygen extraction fraction (OEF) estimations by quantitative
susceptibility mapping plus quantitative blood oxygen-level dependence (QSM+ qBOLD, or …
susceptibility mapping plus quantitative blood oxygen-level dependence (QSM+ qBOLD, or …
Quantitative susceptibility mapping of brain iron and β-amyloid in MRI and PET relating to cognitive performance in cognitively normal older adults
Background For individuals with mild cognitive impairment (MCI) or dementia, elevated
brain iron together with β-amyloid is associated with lower cognitive functioning. But this …
brain iron together with β-amyloid is associated with lower cognitive functioning. But this …
Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study
O Hanon, JS Vidal, S Lehmann… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Blood‐based biomarkers are the next challenge for Alzheimer's disease (AD)
diagnosis and prognosis. Methods Mild cognitive impairment (MCI) participants (N= 485) of …
diagnosis and prognosis. Methods Mild cognitive impairment (MCI) participants (N= 485) of …
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo
Access to metabolic information in vivo using magnetic resonance (MR) technologies has
generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI) …
generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI) …
Validation of T2‐based oxygen extraction fraction measurement with 15O positron emission tomography
Purpose To evaluate the accuracy of T2‐based whole‐brain oxygen extraction fraction
(OEF) estimation by comparing it with gold standard 15O‐PET measurements. Methods …
(OEF) estimation by comparing it with gold standard 15O‐PET measurements. Methods …
Brain oxygen extraction is differentially altered by Alzheimer's and vascular diseases
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their
concurrence, represent the most common types of cognitive dysfunction. Treatment …
concurrence, represent the most common types of cognitive dysfunction. Treatment …
Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer's disease and related dementias
The blood–brain barrier (BBB) plays important roles in the maintenance of brain
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …
[HTML][HTML] MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe
The medial temporal lobe (MTL) is a key area implicated in many brain diseases, such as
Alzheimer's disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL …
Alzheimer's disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL …