Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits
fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop …

G protein-coupled receptors (GPCRs) signal through both G-protein-dependent and G-
protein-independent pathways, and β-arrestin recruitment is the most recognized one of the …

Despite the increasing number of GPCR structures and recent advances in peptide design,
the development of efficient technologies allowing rational design of high-affinity peptide …

Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system,
where they modulate a range of physiological processes depending on their location …

Biased pharmacological modulators provide potential therapeutic benefits, including greater
pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore …

The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means
to modulate pain perception, stress responses, and affective reward states. Therefore, the …

The discovery of biased signaling at G protein-coupled receptors (GPCRs), the largest class
of cell surface receptors and primary drug targets for numerous human diseases, has …

Kappa opioid receptor (KOR) is a member of the opioid receptor system, the G protein-
coupled receptors that are expressed throughout the peripheral and central nervous …

There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor
(KOPr) agonists have been studied for decades but have recently received increased …