CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …

Efficient cancer immunotherapy depends on selective targeting of high bioactivity
therapeutic agents to the tumours. However, delivering exogenous medication might prove …

Conspectus The cytosolic delivery of biomolecules such as genes, proteins, and peptides is
of great importance for biotherapy but usually limited by multiple barriers during the process …

Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …

Combining intracellularly active proteins with chemotherapeutics represents a promising
strategy for synergistic cancer therapy. However, the lack of nanocarrier systems for delivery …

Cytosolic protein delivery is a prerequisite for the development of protein therapeutics that
act on intracellular targets. Proteins are generally membrane‐impermeable and thus need a …

Delivery of functional proteins into the intracellular space has been a challenging task that
could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation …

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …