Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

Myelodysplastic syndromes (MDSs) are a group of heterogeneous clonal hematologic
malignancies that are characterized by defective bone marrow (BM) hematopoiesis and by …

Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk
of progression to acute myeloid leukemia (AML). The mechanisms of transformation of MDS …

Macrothrombocytopenia (MTP) is a heterogeneous group of disorders characterized by
enlarged and reduced numbers of circulating platelets, sometimes resulting in abnormal …

Multiparameter flow cytometry (MFC) is one of the essential ancillary methods in bone
marrow (BM) investigation of patients with cytopenia and suspected myelodysplastic …

RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to
negatively regulate Toll-like receptor 4 (TLR4) signaling through nuclear factor κB (NF-κB) in …

Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms of anemia
in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency of …

Abstract RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q-syndrome, but
mouse models of each gene deficiency recapitulate only a subset of the composite clinical …

TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in
myeloid malignancies with deletion of chromosome 5q. Employing a combination of …

Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of
progressing to hematologic malignancies. CH mutations are predominantly found in aged …