Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be
defined as exercise-induced decrease in the ability to produce force. Here, to provide a …

Nitric oxide (NO) plays a plethora of important roles in the human body. Insufficient
production of NO (for example, during older age and in various disease conditions) can …

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

Much is known about the physiological impairments that can cause muscle fatigue. It is
known that fatigue can be caused by many different mechanisms, ranging from the …

The purpose of this study was to elucidate the mechanistic bases for the reported reduction
in the O2 cost of exercise following short-term dietary nitrate (NO3−) supplementation. In a …

Skeletal muscle phosphorus‐31 31P MRS is the oldest MRS methodology to be applied to
in vivo metabolic research. The technical requirements of 31P MRS in skeletal muscle …

Non‐Technical Summary Reduced atmospheric O2 availability (hypoxia) impairs muscle
oxidative energy production and exercise tolerance. We show that dietary supplementation …

Skeletal muscle fatigue is defined as the fall of force or power in response to contractile
activity. Both the mechanisms of fatigue and the modes used to elicit it vary tremendously …

A growing body of research is investigating the potential contribution of mitochondrial
function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo …