While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Abstract Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal
transition (EMT) in cancer cell dissemination are well established, but the involvement of …

Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …

Background Bone metastasis is the leading cause of tumor‐related death in prostate cancer
(PCa) patients. Long noncoding RNAs (lncRNAs) have been well documented to be …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …

Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …

As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …