[HTML][HTML] Cancer neuroscience: State of the field, emerging directions

F Winkler, HS Venkatesh, M Amit, T Batchelor, IE Demir… - Cell, 2023 - cell.com
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

[HTML][HTML] Tumor microenvironment: barrier or opportunity towards effective cancer therapy

A Tiwari, R Trivedi, SY Lin - Journal of biomedical science, 2022 - Springer
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Neuroimmune cardiovascular interfaces control atherosclerosis

SK Mohanta, L Peng, Y Li, S Lu, T Sun, L Carnevale… - Nature, 2022 - nature.com
Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart
attacks and strokes. As plaques lack innervation, the effects of neuronal control on …

[HTML][HTML] The updated landscape of tumor microenvironment and drug repurposing

MZ Jin, WL Jin - Signal transduction and targeted therapy, 2020 - nature.com
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Stress and cancer: mechanisms, significance and future directions

A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …

[HTML][HTML] Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

[HTML][HTML] Nociceptor neurons affect cancer immunosurveillance

M Balood, M Ahmadi, T Eichwald, A Ahmadi… - Nature, 2022 - nature.com
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

The neuroscience of cancer

R Mancusi, M Monje - Nature, 2023 - nature.com
The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Cancer-derived exosomes: their role in cancer biology and biomarker development

VC Kok, CC Yu - International Journal of Nanomedicine, 2020 - Taylor & Francis
Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and are
present in all body fluids. They are produced actively in tumor cells, which are released and …