Despite the exciting breakthroughs in medical technology, cancer still accounts for one of
the principle triggers of death and conventional therapeutic modalities often fail to attain an …

Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

Purpose FAP is a membrane-bound protease under investigation as a pan-cancer target,
given its high levels in tumors but limited expression in normal tissues. FAP-2286 is a …

Simple Summary This review summarizes recent advances in the nuclear medicine
theranostic approach. It covers the repurposing of historical radiotracers for new indications …

The aim of this work was to explore 132La as a PET imaging surrogate for 225Ac using a
DOTA-based, tumor-targeting alkylphosphocholine (NM600). Methods: 132La was …

The use of conventional methods for the treatment of cancer, such as chemotherapy or
radiotherapy, and approaches such as brachytherapy in conjunction with the unique …

Molecular imaging plays an increasingly important role in the diagnosis and treatment of
different malignancies. Radiolabeled probes enable the visualization of the primary tumor as …

Brain metastases develop in over 60% of advanced melanoma patients and negatively
impact quality of life and prognosis. In a murine melanoma model, we previously showed …

After an initial response to chemotherapy, tumor relapse is frequent. This event is reflective
of both the spatiotemporal heterogeneities of the tumor microenvironment as well as the …