This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

The RASSF1A locus at 3p21. 3 is epigenetically inactivated at high frequency in a variety of
solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …