Disease overview Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell
cancer characterized by unbridled proliferation of malignant marrow stem cells with …

Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …

Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Abstract Uproleselan (GMI-1271) is a novel E-selectin antagonist that disrupts cell survival
pathways, enhances chemotherapy response, improves survival in mouse xenograft and …

Abstract DNA methyltransferase 3 A (DNMT3A) is the most frequently mutated gene in acute
myeloid leukemia (AML). Although chemotherapy agents have improved outcomes for …

Many cancer types metastasize to bone. This propensity may be a product of genetic traits of
the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with …