The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …

The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

The intestinal epithelial lining, together with factors secreted from it, forms a barrier that
separates the host from the environment. In pathologic conditions, the permeability of the …

Paneth cells were first described in the late 19th century by Gustav Schwalbe and Josef
Paneth as columnar epithelial cells possessing prominent eosinophilic granules in their …

The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

Accumulating evidence suggests that the human intestinal microbiota contributes to the
aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific …

Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …

Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …

Damage to the intestinal stem cell niche can result from mechanical stress, infections,
chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to …