Taste receptors are well known for their role in the sensation of taste. Surprisingly, the
expression and involvement of taste receptors in chemosensory processes outside the …

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Background Bitter and sweet taste receptors (T2Rs and T1Rs), respectively, are involved in
the innate immune response of the sinonasal cavity and associated with chronic …

Abstract Background The role of Akt in nasal immunity is unstudied. Akt phosphorylates and
activates endothelial nitric oxide synthase (eNOS) expressed in epithelial ciliated cells. Nitric …

The bitter taste receptors (T2Rs) expressed in human sinonasal mucosae are known to elicit
innate immune responses involving the release of nitric oxide (NO). We investigated the …

Background Eosinophilic inflammation is a hallmark of refractory chronic rhinosinusitis
(CRS) and considered a major therapeutic target. Autophagy deficiency in myeloid cells …

Studies have shown differences in TAS2R38 receptor expression in patients with chronic
rhinosinusitis (CRS) compared to healthy controls. Known agonists of TAS2R38 stimulate …

Background Innate immunity response to local dysbiosis seems to be one of the most
important immunologic backgrounds of chronic rhinosinusitis (CRS) and concomitant …

Background: Recent studies reported the relationship between genetic variations and
TAS2R38, which is a bitter taste receptor expressed in the cilia of human sinonasal …

Nnabue et al. 16 used histological techniques and high-resolution confocal microscopy to
demonstrate a significant decrease in gland density in the posterior septum of patients with …