Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …

The genetic compensation response (GCR) has recently been proposed as a possible
explanation for the phenotypic discrepancies between gene-knockout and gene …

The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …

Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic
messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the …

The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …

Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …