Food, gastrointestinal pH, and models of oral drug absorption
AY Abuhelwa, DB Williams, RN Upton… - European journal of …, 2017 - Elsevier
This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …
Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its …
D Liu, Y Mao, L Ding, XA Zeng - Trends in Food Science & Technology, 2019 - Elsevier
Background Dihydromyricetin (DMY) is an important plant flavonoid, which has received
great attention due to its health-benefiting activities, including antioxidant, antimicrobial, anti …
great attention due to its health-benefiting activities, including antioxidant, antimicrobial, anti …
[HTML][HTML] An atlas of β-glucuronidases in the human intestinal microbiome
RM Pollet, EH D'Agostino, WG Walton, Y Xu, MS Little… - Structure, 2017 - cell.com
Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health
by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of …
by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of …
[HTML][HTML] Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania
Growth impairment is a major public health issue for children in Tanzania. The question
remains as to whether dietary mycotoxins play a role in compromising children's growth. We …
remains as to whether dietary mycotoxins play a role in compromising children's growth. We …
[HTML][HTML] Food effects on oral drug absorption: application of physiologically-based pharmacokinetic modeling as a predictive tool
The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …
physicochemical characteristics and is influenced by many biological processes. For …
Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability
Enteric coating is a common procedure in the development of oral pharmaceutical dosage
forms. The main advantage of enteric coating is that it protects the drug from acidic pH and …
forms. The main advantage of enteric coating is that it protects the drug from acidic pH and …
Food for thought: formulating away the food effect–a PEARRL review
Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents
S Das - International Journal of Pharmaceutics, 2021 - Elsevier
In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-
triggered release approach has several advantages over other approaches due to unique …
triggered release approach has several advantages over other approaches due to unique …
[HTML][HTML] Intestinal and fecal pH in human health
R Yamamura, KY Inoue, K Nishino… - Frontiers in …, 2023 - frontiersin.org
Gut microbiota has been reported to be closely related to host energy metabolism and
immunity, and thus influence the development and progression of various human diseases …
immunity, and thus influence the development and progression of various human diseases …
[HTML][HTML] Pharmacokinetics of obese adults: Not only an increase in weight
J Gouju, S Legeay - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …
characterized by an adipose tissue accumulation leading to an important weight increased …