Unveiling the Venom Composition of the Colombian Coral Snakes Micrurus helleri, M. medemi, and M. sangilensis

A Rodríguez-Vargas, AM Franco-Vásquez… - Toxins, 2023 - mdpi.com
Little is known of the biochemical composition and functional features of the venoms of
poorly known Colombian coral snakes. Here, we provide a preliminary characterization of …

Knowledge about snake venoms and toxins from Colombia: a systematic review

JA Pereañez, LM Preciado, P Rey-Suárez - Toxins, 2023 - mdpi.com
Colombia encompasses three mountain ranges that divide the country into five natural
regions: Andes, Pacific, Caribbean, Amazon, and Orinoquia. These regions offer an …

Anticoagulant Micrurus venoms: Targets and neutralization

D Dashevsky, M Benard-Valle, E Neri-Castro… - Toxicology Letters, 2021 - Elsevier
Snakebite is a neglected tropical disease with a massive global burden of injury and death.
The best current treatments, antivenoms, are plagued by a number of logistical issues that …

Snakebite by Micrurus averyi (Schmidt, 1939) in the Brazilian Amazon basin: Case report

IM da Silva, JC Bernal, PFG Bisneto, AM Tavares… - Toxicon, 2018 - Elsevier
Micrurus snakes, commonly known as coral snakes, are responsible for 0.4% of the
snakebites envenomings in Brazil. In this report, we describe a case of envenoming by …

Anti-Neurotoxins from Micrurus mipartitus in the Development of Coral Snake Antivenoms

A Cardona-Ruda, P Rey-Suárez, V Núñez - Toxins, 2022 - mdpi.com
In Colombia, the genus Micrurus includes 30 species, of which M. mipartitus and M. dumerilii
are the most widely distributed. Micrurus causes less than 3% of the approximately 5000 …

Functional venomics of the Big-4 snakes of Pakistan

SU Hashmi, A Alvi, I Munir, M Perveen, A Fazal… - Toxicon, 2020 - Elsevier
Abstract In South Asia, the “Big-4” venomous snakes Naja naja, Bungarus caeruleus,
Daboia russelii, and Echis carinatus are so-called because they are the most medically …

Antibodies against a single fraction of Micrurus dumerilii venom neutralize the lethal effect of whole venom

J Gómez-Robles, P Rey-Suárez, JA Pereañez… - Toxicology Letters, 2023 - Elsevier
Abstract The coralsnake Micrurus dumerilii (Elapidae) is reported to cause envenomings of
medical importance. Previous studies characterized the protein composition of its venom …

Production of a recombinant phospholipase A2 in Escherichia coli using resonant acoustic mixing that improves oxygen transfer in shake flasks

NA Valdez-Cruz, GI Reynoso-Cereceda… - Microbial Cell …, 2017 - Springer
Background Shake flasks are widely used during the development of bioprocesses for
recombinant proteins. Cultures of recombinant Escherichia coli with orbital mixing (OM) …

Heterologous Expression and Immunogenic Potential of the Most Abundant Phospholipase A2 from Coral Snake Micrurus dumerilii to Develop Antivenoms

LE Romero-Giraldo, S Pulido, MA Berrío, MF Flórez… - Toxins, 2022 - mdpi.com
Micrurus dumerilii is a coral snake of clinic interest in Colombia. Its venom is mainly
composed of phospholipases A2 being MdumPLA2 the most abundant protein …

Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA2 Molecules from Coral Snakes

C Corrêa-Netto, MA Strauch, M Monteiro-Machado… - Toxins, 2022 - mdpi.com
For over a century, polyclonal antibodies have been used to treat snakebite envenoming
and are still considered by the WHO as the only scientifically validated treatment for …