Super-resolution microscopy demystified
Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier that
restricts the optical resolution to roughly 250 nm and was previously thought to be …
restricts the optical resolution to roughly 250 nm and was previously thought to be …
Once and only once: mechanisms of centriole duplication and their deregulation in disease
EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin
Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …
Centrosome function and assembly in animal cells
PT Conduit, A Wainman, JW Raff - Nature reviews Molecular cell …, 2015 - nature.com
It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …
microtubule organizers. There is increasing evidence that they also function as coordination …
Mechanism and regulation of centriole and cilium biogenesis
DK Breslow, AJ Holland - Annual review of biochemistry, 2019 - annualreviews.org
The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …
symmetry. Centrioles form the core of centrosomes, which organize the interphase …
The centrosome and its duplication cycle
The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …
Long recognized as a key organelle of the spindle pole, its core component, the centriole …
Microtubule nucleation by γ-tubulin complexes and beyond
CA Tovey, PT Conduit - Essays in biochemistry, 2018 - portlandpress.com
In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30
years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for …
years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for …
Regulated assembly of a supramolecular centrosome scaffold in vitro
JB Woodruff, O Wueseke, V Viscardi, J Mahamid… - Science, 2015 - science.org
The centrosome organizes microtubule arrays within animal cells and comprises two
centrioles surrounded by an amorphous protein mass called the pericentriolar material …
centrioles surrounded by an amorphous protein mass called the pericentriolar material …
Structural basis for mitotic centrosome assembly in flies
Summary In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that
recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear …
recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear …
A perinuclear microtubule-organizing centre controls nuclear positioning and basement membrane secretion
Y Zheng, RA Buchwalter, C Zheng, EM Wight… - Nature cell …, 2020 - nature.com
Non-centrosomal microtubule-organizing centres (ncMTOCs) have a variety of roles that are
presumed to serve the diverse functions of the range of cell types in which they are found …
presumed to serve the diverse functions of the range of cell types in which they are found …