[HTML][HTML] The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …
a variety of cell types, whose activity and interplay must be precisely mediated for effective …
[HTML][HTML] The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases
K Wojciechowicz, M Spodzieja, KA Lisowska… - Cellular …, 2022 - Elsevier
Autoimmune diseases constitute a heterogeneous group of disorders with one common
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …
feature–the loss of immune tolerance towards autoantigens. Due to the complexity of the …
Perspective insights of small molecules, phytoconstituents and biologics in the management of psoriasis: A focus on targeting major inflammatory cytokine pathways
H Kadagothy, S Nene, E Amulya, G Vambhurkar… - European Journal of …, 2023 - Elsevier
Psoriasis is an enduring, pruritic and papulosquamous skin ailment that poses a significant
burden on public health. It is mainly characterized by hyperkeratosis, acanthosis …
burden on public health. It is mainly characterized by hyperkeratosis, acanthosis …
TIGIT: An emerging immune checkpoint target for immunotherapy in autoimmune disease and cancer
J Zhao, L Li, H Yin, X Feng, Q Lu - International immunopharmacology, 2023 - Elsevier
Immune checkpoints (ICs), also referred to as co-inhibitory receptors (IRs), are essential for
regulating immune cell function to maintain tolerance and prevent autoimmunity. IRs, such …
regulating immune cell function to maintain tolerance and prevent autoimmunity. IRs, such …
Lymphocyte activation gene-3 (LAG-3) regulatory T cells: An evolving biomarker for treatment response in autoimmune diseases
S Gertel, A Polachek, O Elkayam, V Furer - Autoimmunity Reviews, 2022 - Elsevier
Regulatory T cells (Tregs) comprise a CD4+ CD25+ Foxp3+ T cell subset for maintaining
immune tolerance, and their deficits and/or dysfunction are observed in autoimmune …
immune tolerance, and their deficits and/or dysfunction are observed in autoimmune …
[HTML][HTML] Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells
J Ma, S Yan, Y Zhao, H Yan, Q Zhang, X Li - Frontiers in Immunology, 2023 - frontiersin.org
Background The diffuse large B-cell lymphoma (DLBCL) has the highest incidence of all
lymphomas worldwide. To investigate the functions of lymphocyte activation gene 3 (LAG-3) …
lymphomas worldwide. To investigate the functions of lymphocyte activation gene 3 (LAG-3) …
'Transfersome-embedded-gel'for dual-mechanistic delivery of anti-psoriatic drugs to dermal lymphocytes
Aim Develop a platform for co-delivering clobetasol propionate (CP) and cyclosporine (CyA)
to the epidermis and dermis to treat psoriasis. Methods The transfersomes were prepared by …
to the epidermis and dermis to treat psoriasis. Methods The transfersomes were prepared by …
CD4+LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restoration in vitro is mediated by TNF inhibitors
S Gertel, A Polachek, V Furer… - Clinical & …, 2021 - academic.oup.com
Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with T cell
dysregulation. The lymphocyte-activation gene (LAG)-3 is one of the regulatory receptors …
dysregulation. The lymphocyte-activation gene (LAG)-3 is one of the regulatory receptors …
Nobel Prize for immune checkpoint inhibitors, understanding the immunological switching between immunosuppression and autoimmunity
IG Motofei - Expert opinion on drug safety, 2022 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are a revolutionary form of
immunotherapy in cancer. However, the percentage of patients responding to therapy is …
immunotherapy in cancer. However, the percentage of patients responding to therapy is …
Analysis of scRNA-seq and bulk RNA-seq demonstrates the effects of EVI2B or CD361 on CD8+ T cells in osteosarcoma
T Xie, W Feng, M He, X Zhan, S Liao… - Experimental …, 2023 - journals.sagepub.com
Osteosarcoma (OS) is a common primary malignant tumor of the bone in children and
adolescents. The five-year survival rate is estimated to be~ 70% based on the currently …
adolescents. The five-year survival rate is estimated to be~ 70% based on the currently …