Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

In vertebrates, peripheral chemosensory neurons express large families of G protein-
coupled receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect …

The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role
in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and …

Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations
of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch …

Abstract FMRFamide (Phe‐Met‐Arg‐Phe‐NH2) and related peptides (FaRPs) have been
found throughout the animal kingdom, where they are involved in many behaviors. We …

The two mammalian neuropeptides NPFF and NPAF have been shown to have important
roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors …

Identification of novel neurohormones that play important roles in the regulation of pituitary
function is essential for the progress of neurobiology. The decapeptide gonadotropin …

Neuropeptide FF (NPFF) has been proposed to play a role in pain modulation, opioid
tolerance, and several other physiological processes. However, pharmacological agents …

Orexin‐A and orexin‐B (also known as hypocretin‐1 and hypocretin‐2) are hypothalamic
peptides and regulate feeding behaviour, energy metabolism and the sleep‐wake cycle …