Simple Summary CHUK/IKKα has emerged as a novel tumor suppressor in several organs
of humans and mice. In general, activation of NF-κB promotes inflammation and …

Angiogenesis is regulated by numerous “classic” factors such as vascular endothelial
growth factor (VEGF) and many other endogenous “non-classic” peptides, including …

Diabetic wounds management remains a significant global challenge due to impaired
wounds healing, bleeding, and infection. Oxidative stress (OS), resulting from dysregulated …

Purpose: Most patients with ovarian cancer receive paclitaxel chemotherapy, but less than
half respond. Pre-treatment microtubule stability correlates with paclitaxel response in …

The tumor microenvironment (TME) provides potential targets for cancer therapy. However,
how signals originating in cancer cells affect tumor-directed immunity is largely unknown …

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is one of important kinases in
inflammation to phosphorylate inhibitor of nuclear factor kappa-B (IκBα) and then activate …

Background Esophageal cancer is the most common cause of cancer-related death
worldwide with a diverse geographical distribution, poor prognosis, and diagnosis in …

The challenge to improve the clinical efficacy and enlarge the population that benefits from
immune checkpoint inhibitors (ICIs) for non‐small‐cell lung cancer (NSCLC) is significant …

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain
insight into the pathogenesis of esophageal diseases, which are among the leading causes …

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a kinase principally known
as a positive regulator of the ubiquitous transcription factor family Nuclear Factor-kappa B …