Microbiota medicine: towards clinical revolution

P Gebrayel, C Nicco, S Al Khodor, J Bilinski… - Journal of translational …, 2022 - Springer
The human gastrointestinal tract is inhabited by the largest microbial community within the
human body consisting of trillions of microbes called gut microbiota. The normal flora is the …

[HTML][HTML] Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

[HTML][HTML] The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?

B Misiak, I Łoniewski, W Marlicz, D Frydecka… - Progress in Neuro …, 2020 - Elsevier
Accumulating evidence indicates that patients with severe mental disorders, including major
depression, bipolar disorder and schizophrenia present with various alterations of the gut …

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

JM Safadi, AMG Quinton, BR Lennox, PWJ Burnet… - Molecular …, 2022 - nature.com
Reduced gut-microbial diversity (“gut dysbiosis”) has been associated with an anhedonic/
amotivational syndrome (“sickness behavior”) that manifests across severe mental disorders …

Altered gut microbiota associated with symptom severity in schizophrenia

S Li, M Zhuo, X Huang, Y Huang, J Zhou, D Xiong, J Li… - PeerJ, 2020 - peerj.com
Background The gut microbiome and microbiome-gut-brain (MGB) axis have been receiving
increasing attention for their role in the regulation of mental behavior and possible biological …

[HTML][HTML] Psychotropics and the microbiome: a chamber of secrets…

S Cussotto, G Clarke, TG Dinan, JF Cryan - Psychopharmacology, 2019 - Springer
The human gut contains trillions of symbiotic bacteria that play a key role in programming
different aspects of host physiology in health and disease. Psychotropic medications act on …

Microbiome—the missing link in the gut-brain axis: focus on its role in gastrointestinal and mental health

K Skonieczna-Żydecka, W Marlicz, A Misera… - Journal of clinical …, 2018 - mdpi.com
The central nervous system (CNS) and the human gastrointestinal (GI) tract communicate
through the gut-brain axis (GBA). Such communication is bi-directional and involves …

[HTML][HTML] The burden of antipsychotic-induced weight gain and metabolic syndrome in children

MR Libowitz, EL Nurmi - Frontiers in Psychiatry, 2021 - frontiersin.org
Antipsychotic medications are critical to child and adolescent psychiatry, from the
stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic …

Clinical significance of microbiota changes under the influence of psychotropic drugs. An updated narrative review

A Misera, I Łoniewski, J Palma, M Kulaszyńska… - Frontiers in …, 2023 - frontiersin.org
Relationship between drugs and microbiota is bilateral. Proper composition thus function of
microbiota is a key to some medications used in modern medicine. However, there is also …

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: A scoping review

R Singh, N Stogios, E Smith, J Lee… - Therapeutic …, 2022 - journals.sagepub.com
Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability
rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as …