Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized
by excessive synthesis, remodeling, and contraction of extracellular matrix produced by …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

Biological tissues exhibit complex spatial heterogeneity that directs the functions of
multicellular organisms. Quantifying protein expression is essential for elucidating …

The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …