The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic …

Current concepts of the pathogenesis of Parkinson's disease (PD) center on the formation of
reactive oxygen species and the onset of oxidative stress leading to oxidative damage to …

Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

Mitochondrial dysfunction and oxidative stress characterize major factors involved in the
activation of complex processes corresponding to apoptosis‐mediated neuronal …

Current concepts of the cause of Parkinson's disease (PD) suggest a role for both genetic
and environmental influences. Common to a variety of potential causes of nigral cell …

We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

Parkinson's disease (PD) is a progressive neurodegenerative disease involving
neurodegeneration of dopaminergic neurons of the substantia nigra (SN), a part of the …

Initialydescribed byTalan etal,[1], N-acetylaspar-tate (NAA) isfoundatvery high
concentrationsin the nammalian brain (6—7umol/gin human brain) andis SecondOnlytoglutamateintermsoffreeamino …

Unlike most other cell types, neurons preferentially metabolize glucose via the pentose
phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal …