Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Preeclampsia is becoming an increasingly common diagnosis in the developed world and
remains a high cause of maternal and fetal morbidity and mortality in the developing world …

Abstract Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising
as a result of oxidative and inflammatory insults. Tremendous research has been carried out …

Oxidative stress and inflammation are mediators in the development and progression of
chronic kidney disease (CKD) and its complications, and they are inseparably linked as …

Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …

Stem cells are self-renewing cells that can differentiate into specialized cell type (s).
Pluripotent stem cells, ie embryonic stem cells (ESC) or induced pluripotent stem cells …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte
apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …