Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …

Evidence from the literature keeps highlighting the impact of mutualistic bacterial
communities of the gut microbiota on human health. The gut microbita is a complex …

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …

Objective To investigate the variations in body weight, food intake, and body composition of
both male and female C57BL/6J mice during a diet‐induced obesity model with high‐fat diet …

An inability of adipose tissue to expand consequent to exhausted capacity to recruit new
adipocytes might underlie the association between obesity and insulin resistance …

Obesity, characterized by excessive adiposity, is a risk factor for many metabolic
pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies have shown that …

The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are
structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the …

Despite high leptin levels, most obese humans and rodents lack responsiveness to its
appetite-suppressing effects. We demonstrate that leptin modulates NPY/AgRP and α-MSH …