c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …

In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …

According to a “canonical” view, reactive oxygen species (ROS) positively contribute, in
different ways, to carcinogenesis and to malignant progression of tumor cells: they drive …

G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins
belonging to a large family of cell-surface receptors involved in many intracellular signaling …

Identification of specific gene expression signatures characteristic of oncogenic pathways is
an important step toward molecular classification of human malignancies. Aberrant …

The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated
in concert with master developmental and oncogenic pathways regulating in tumor growth …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and
its burden is expected to increase further in the next years. In spite of the advances of …