An overview of the c-MET signaling pathway
SL Organ, MS Tsao - Therapeutic advances in medical …, 2011 - journals.sagepub.com
c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …
factor, activates a wide range of different cellular signaling pathways, including those …
New insights into modes of GPCR activation
W Wang, Y Qiao, Z Li - Trends in pharmacological sciences, 2018 - cell.com
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …
heterotrimeric G proteins on the membrane and then activate downstream signaling …
Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II
L Hunyady, KJ Catt - Molecular endocrinology, 2006 - academic.oup.com
Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
CA Bradley, M Salto-Tellez, P Laurent-Puig… - Nature reviews Clinical …, 2017 - nature.com
Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
A review of anti-angiogenic targets for monoclonal antibody cancer therapy
DH Kong, MR Kim, JH Jang, HJ Na, S Lee - International journal of …, 2017 - mdpi.com
Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …
Metastasis: cancer cell's escape from oxidative stress
G Pani, T Galeotti, P Chiarugi - Cancer and Metastasis Reviews, 2010 - Springer
According to a “canonical” view, reactive oxygen species (ROS) positively contribute, in
different ways, to carcinogenesis and to malignant progression of tumor cells: they drive …
different ways, to carcinogenesis and to malignant progression of tumor cells: they drive …
Cell-surface receptors transactivation mediated by g protein-coupled receptors
F Cattaneo, G Guerra, M Parisi, M De Marinis… - International journal of …, 2014 - mdpi.com
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins
belonging to a large family of cell-surface receptors involved in many intracellular signaling …
belonging to a large family of cell-surface receptors involved in many intracellular signaling …
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
P Kaposi-Novak, JS Lee… - The Journal of …, 2006 - Am Soc Clin Investig
Identification of specific gene expression signatures characteristic of oncogenic pathways is
an important step toward molecular classification of human malignancies. Aberrant …
an important step toward molecular classification of human malignancies. Aberrant …
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
M Sabbah, S Emami, G Redeuilh, S Julien… - Drug resistance …, 2008 - Elsevier
The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated
in concert with master developmental and oncogenic pathways regulating in tumor growth …
in concert with master developmental and oncogenic pathways regulating in tumor growth …
[HTML][HTML] Met as a therapeutic target in HCC: facts and hopes
S Giordano, A Columbano - Journal of hepatology, 2014 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and
its burden is expected to increase further in the next years. In spite of the advances of …
its burden is expected to increase further in the next years. In spite of the advances of …