In the middle of the 20th century, it was postulated that degradation of intracellular proteins
is a stochastic process. More than fifty years of intense studies have finally proven that …

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in
autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively …

ABSTRACT A majority of thousands of intracellular mammalian proteins are recognized by
proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation …

Astrocytes are considered to be an important contributor to central nervous system (CNS)
disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected …

Proteasomes exist in mammalian cells in multiple combinatorial variants due to the diverse
regulatory particles and exchange of catalytic subunits. Here, using biotin carboxyl carrier …

Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively
produce and uptake polyamines such as spermine. Here, we show that various amines …

Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its
binding to the proteasome and decelerates its degradation by the proteasome in …

Glatiramer acetate, formerly called copolymer-1, is one of a series of polypeptide
preparations developed to stimulate myelin basic protein, a natural component of the myelin …

Деиминирование основного белка миелина (MBP) пептидиларгининдеиминазой (PAD)
препятствует его связыванию с протеасомой и замедляет его деградацию при …

ТЕЗИСЫ МЕЖДУНАРОДНОЙ КОНФЕРЕНЦИИ "MOLECULAR MECHANISMS OF GROWTH
AND PROGRESSION OF MALIGNANT NEOPLASMS", ПОСВЯЩЕННОЙ 55-ЛЕТИЮ …