NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Neutrophils are essential to the homeostatic mission of safeguarding host tissues,
responding rapidly and diversely to breaches of the host's barriers to infection, and returning …

Dry Eye Dry eye is a common, painful ocular disturbance that can result from systemic
inflammatory diseases, localized eye problems, or commonly used medications. Current …

Most patients with chronic dry eye disease (DED) have episodic flares, which can be
triggered by a variety of activities and environmental stresses. These flares are typically …

Neutrophil extracellular traps (NETs), the product of NETosis, is found to localize pathogens
and crystals in immune response. Recent studies have found that excessive NETs lead to …

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Purpose To investigate the role of neutrophil extracellular traps (NETs) and NET-associated
proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …

Neutrophils are the most numerous cells in the leukocyte population and essential for innate
immunity. To limit their effector functions, neutrophils are able to modulate glycolysis and …