Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting
mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs)(such as PD-1 and …

Inflammasomes are crucial for innate immunity against infections and, when deregulated,
also contribute to inflammatory diseases. Here, we identify a critical function of the E3 …

Background The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to
several human cancer development and progression. However, its expression patterns and …

Changes in the DNA damage response (DDR) and cellular metabolism are two important
factors that allow cancer cells to proliferate. DDR is a set of events in which DNA damage is …

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed
in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely …

Background Pancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is
characterized by difficulties in early diagnosis, early metastasis, limited therapeutic response …

Autophagy flux is impaired during myocardial ischemia/reperfusion (MI/R) via the
accumulation of autophagosome and insufficient clearance, which exacerbates …

Objective The abnormal expansion of Tfh cells plays a key role in chronic inflammation of
RA joint. We speculated that STUB1 is an important regulatory factor in promoting the …

CD8+ T cells are an important component of the body's adaptive immune response. During
viral or intracellular bacterial infections, CD8+ T cells are rapidly activated and differentiated …