Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated
with marked morbidity and mortality. The contemporary diagnostic and therapeutic …

The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous
system, play host to various pathologies including infection, neuroinflammation and …

Leptomeningeal disease (LMD) remains a major challenge in the clinical management of
metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD …

Background Leptomeningeal disease (LMD) occurs as a late complication of several human
cancers and has no rationally designed treatment options. A major barrier to developing …

Melanoma-associated leptomeningeal disease (M-LMD) occurs when circulating tumor cells
(CTCs) enter into the cerebral spinal fluid (CSF) and colonize the meninges, the membrane …

Leptomeningeal metastases (LM) is a rare but devastating complication of advanced cancer.
Advances in cancer treatment has markedly improved the survival, nonetheless, due to the …