Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer
(CRC) generally characterized by clinical symptoms, including malabsorption, intestinal …

Vitamin K is essential for several physiological processes, such as blood coagulation, in
which it serves as a cofactor for the conversion of peptide-bound glutamate to γ …

In contrast to other fat-soluble vitamins, dietary vitamin K is rapidly lost to the body resulting
in comparatively low tissue stores. Deficiency is kept at bay by the ubiquity of vitamin K in the …

Vitamin K‐dependent proteins require carboxylation of certain glutamates for their biological
functions. The enzymes involved in the vitamin K‐dependent carboxylation include: gamma …

Vitamin K (VK) is an essential cofactor for the post-translational conversion of peptide-bound
glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or …

Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification,
which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is …

Human vitamin K 2, 3-epoxide reductase complex subunit 1-like 1 (VKORC1L1), expressed
in HEK 293T cells and localized exclusively to membranes of the endoplasmic reticulum …

Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy
expenditure, male fertility, brain development, and cognition. Before being secreted by …

The vitamin K oxidoreductase (VKOR) reduces vitamin K to support the carboxylation and
consequent activation of vitamin K-dependent proteins, but the mechanism of reduction is …

Background: Effective involvement of VKORC1L1 in vitamin K epoxide reductase activity,
target of vitamin K antagonists (VKAs), is still unclear. Results: VKORC1L1 is not inhibited by …