Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Autosomal dominant cerebellar ataxias are hereditary neurodegenerative disorders that are
known as spinocerebellar ataxias (SCA) in genetic nomenclature. In the pregenomic era …

Inhibition of polyglutamine-induced protein aggregation could provide treatment options for
polyglutamine diseases such as Huntington disease. Here we showed through in vitro …

Huntington's disease is a progressive neurodegenerative disorder caused by a
polyglutamine [poly (Q)] repeat expansion in the first exon of the huntingtin protein …

Numerous human diseases are associated with the chronic expression of misfolded and
aggregation-prone proteins. The expansion of polyglutamine residues in unrelated proteins …

At least nine inherited neurodegenerative diseases share a polyglutamine expansion in
their respective disease proteins. These diseases show distinct neuropathological changes …

We tested whether proteins implicated in Huntington's and other polyglutamine (polyQ)
expansion diseases can cause axonal transport defects. Reduction of Drosophila huntingtin …

Genetic etiologies of at least 20% of autosomal dominant cerebellar ataxias (ADCAs) have
yet to be clarified. We identified a novel spinocerebellar ataxia (SCA) form in four Japanese …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of
the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be …