The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …

Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

The nephron is the basic structural and functional unit of the vertebrate kidney. It is
composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the …

Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …

NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic
syndrome and low post-transplant recurrence. Background Mutations of NPHS2 are …

Podocytes are unique cells with a complex cellular organization. With respect to their
cytoarchitecture, podocytes may be divided into three structurally and functionally different …