Introduction: The search for vaccines to prevent human leishmaniasis is an active field of
investigation aimed to prevent the devastating effects of this family of diseases on human …

Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus
Leishmania, belonging to a group of neglected tropical diseases. It establishes significant …

Chagas' disease is caused by the protozoan Trypanosoma cruzi, described in the early 20th
century by the Brazilian physician Dr. Carlos Chagas. There was a great amount of research …

Sensing of microbes or of danger signals has mainly been attributed to myeloid innate
immune cells. However, T and B cells also express functional pattern recognition receptors …

Leishmaniasis is a vector-borne Neglected Tropical Disease (NTD) transmitted by the sand
fly and is a major public health problem worldwide. Infections caused by Leishmania …

The African trypanosome survives the immune response of its mammalian host by antigenic
variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we …

Trypanosoma cruzi infection induces a polyclonal B cell proliferative response characterized
by maturation to plasma cells, excessive generation of germinal centers, and secretion of …

Abstract Leishmania elongation factor 2 (EF-2) has been previously identified as a TH 1-
stimulatory protein. In this study, we assayed the protective potential of the N-terminal …

Research on vaccines against trypanosomatids, a family of protozoa that cause neglected
tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a …

We evaluated the epidemiological, hematological, and pathological data of Leishmania
spp., Toxoplasma gondii, Platynosomum illiciens, feline immunodeficiency virus (FIV), and …