Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Purpose Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth
factor receptor, platelet-derived growth factor receptor, and c-Kit. This randomized, double …

Purpose A randomized, phase III trial demonstrated superiority of sunitinib over interferon
alfa (IFN-α) in progression-free survival (primary end point) as first-line treatment for …

Analyses of compounds in clinical development have shown that ligand efficient-molecules
with privileged physical properties and low dose are less likely to fail in the various stages of …

Monocytes and macrophages are major components of the tumor microenvironment, but
their contributions to human cancer are poorly understood. We used molecular profiling …

Purpose: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an
important clinical problem, but its underlying mechanisms are largely unknown. We …

Protein kinases catalyse key phosphorylation reactions in signalling cascades that affect
every aspect of cell growth, differentiation and metabolism. The kinases have become prime …

OBJECTIVE. The purpose of this article is to review cancer-and therapy-specific tumor
response assessment criteria used in clinical trials and in practice, with illustrative case …

Abstract Hand-foot syndrome (HFS), also called hand-foot skin reaction, palmar-plantar
erythrodysesthesia, acral erythema, and Burgdorf reaction, is a dose-limiting cutaneous …