[图书][B] Pathway analysis and optimization in metabolic engineering
Facility in the targeted manipulation of the genetic and metabolic composition of organisms,
combined with unprecedented computational power, is forging a niche for a new …
combined with unprecedented computational power, is forging a niche for a new …
Production of L-carnitine by secondary metabolism of bacteria
The increasing commercial demand for L-carnitine has led to a multiplication of efforts to
improve its production with bacteria. The use of different cell environments, such as growing …
improve its production with bacteria. The use of different cell environments, such as growing …
Metabolic modeling: a tool of drug discovery in the post-genomic era
EO Voit - Drug discovery today, 2002 - Elsevier
The Human Genome Project, DNA microarrays, proteome chips and metabolic profiles,
among others, are generating unprecedented amounts of valuable information about the …
among others, are generating unprecedented amounts of valuable information about the …
Optimization of biochemical systems through mathematical programming: Methods and applications
In this work we present a general (mono and multiobjective) optimization framework for the
technological improvement of biochemical systems. The starting point of the method is a …
technological improvement of biochemical systems. The starting point of the method is a …
Salt stress effects on the central and carnitine metabolisms of Escherichia coli
The aim was to understand how interaction of the central carbon and the secondary
carnitine metabolisms is affected under salt stress and its effect on the production of l …
carnitine metabolisms is affected under salt stress and its effect on the production of l …
Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor
B Zelić, Đ Vasić-Rački, C Wandrey, R Takors - Bioprocess and Biosystems …, 2004 - Springer
A family of 10 competing, unstructured models has been developed to model cell growth,
substrate consumption, and product formation of the pyruvate producing strain Escherichia …
substrate consumption, and product formation of the pyruvate producing strain Escherichia …
Metabolic adaptation of Escherichia coli to long-term exposure to salt stress
The aim of this work was to understand the relevance of central carbon metabolism in salt
stress adaptation of Escherichia coli. The cells were grown anaerobically in batch and …
stress adaptation of Escherichia coli. The cells were grown anaerobically in batch and …
Modeling, optimization and experimental assessment of continuous L‐(−)‐carnitine production by Escherichia coli cultures
F Alvarez‐Vasquez, M Canovas… - Biotechnology and …, 2002 - Wiley Online Library
In a previous paper Cánovas et al.(Biotechnol Bioeng 2002; 77: 764–775) presented a
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …
Modelling of enzyme kinetics: cellulose enzymatic hydrolysis case
M Olkiewicz, B Tylkowski, JM Montornés… - Physical Sciences …, 2022 - degruyter.com
Enzymes as industrial biocatalysts offer numerous advantages over traditional chemical
processes resulting on improvements in process economy and environmental sustainability …
processes resulting on improvements in process economy and environmental sustainability …
Two-Step Production of Phenylpyruvic Acid from L-Phenylalanine by Growing and Resting Cells of Engineered Escherichia coli: Process Optimization and Kinetics …
Phenylpyruvic acid (PPA) is widely used in the pharmaceutical, food, and chemical
industries. Here, a two-step bioconversion process, involving growing and resting cells, was …
industries. Here, a two-step bioconversion process, involving growing and resting cells, was …