Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development

AV Samarelli, V Masciale, B Aramini, GP Coló… - International journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of Translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

[HTML][HTML] Mechanical forces: The missing link between idiopathic pulmonary fibrosis and lung cancer

C Wang, J Yang - European Journal of Cell Biology, 2022 - Elsevier
Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …

Comorbidities in idiopathic pulmonary fibrosis: an underestimated issue

A Caminati, C Lonati, R Cassandro… - European …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and fibrosing lung disease with a poor
prognosis. Between 60% and 70% of IPF patients die of IPF; the remaining causes of death …

Immune checkpoint inhibitor-related pneumonitis

G Gomatou, V Tzilas, E Kotteas, K Syrigos, D Bouros - Respiration, 2021 - karger.com
Immune checkpoint inhibitors are novel agents that have been proved efficacious in a
variety of cancer types, but they are associated with a unique set of organ-specific, immune …

A causal atlas on comorbidities in idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study

J Zhu, D Zhou, J Wang, Y Yang, D Chen, F He, Y Li - Chest, 2023 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a high burden of
both pulmonary and extrapulmonary comorbidities. Research Question Do these …

Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway

Y Lu, W Zhong, Y Liu, Z Zeng, H Huang, X Wan… - International …, 2022 - Elsevier
Pulmonary fibrosis is a fatal lung disease for which no effective treatment is available.
Previous studies have shown that the expression of programmed cell death-Ligand (PD-L1) …

Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease

L Wang, Y Zhang, Z Song, Q Liu, D Fan, X Song - Food & Function, 2023 - pubs.rsc.org
Lung cancer is the malignancy with the highest morbidity and mortality. Additionally,
pulmonary inflammatory diseases, such as pneumonia, acute lung injury, chronic obstructive …