The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable,
though as yet unrealised, therapeutic potential. Promising preclinical data supports the …

Unactivated olefins are converted to alkyl azides with bench-stable NaN3 in the presence of
FeCl3· 6H2O under blue-light irradiation. The products are obtained with anti-Markovnikov …

Immunolabeling and autoradiography have traditionally been applied as the methods-of-
choice to visualize and collect molecular information about physiological and pathological …

Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation
and other diseases. However, a lack of understanding of its complex signaling in cells and …

Despite its essential role in the (patho) physiology of several diseases, CB2R tissue
expression profiles and signaling mechanisms are not yet fully understood. We report the …

The distribution and roles of the cannabinoid CB2 receptor in the CNS are still a matter of
debate. Recent data suggest that, in addition to its presence in microglial cells, the CB2 …

Conspectus Signaling lipids, such as the endocannabinoids, play an important role in the
brain. They regulate synaptic transmission and control various neurophysiological …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands
with a tailored functional response. The present study discloses the structure-based design …