Replication perturbations activate DNA damage tolerance (DDT) pathways, which are
crucial to promote replication completion and to prevent fork breakage, a leading cause of …

Faithful transmission of genetic material is crucial for all organisms since changes in genetic
information may result in genomic instability that causes developmental disorders and …

PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps.
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …

Background DNA replication plays an important role in mutagenesis, yet little is known about
how it interacts with other mutagenic processes. Here, we use somatic mutation signatures …

Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin
structure establishment via elusive mechanisms. Here we examined how specific replication …

Template switching (TS) mediates damage bypass via a recombination-related mechanism
involving PCNA polyubiquitination and polymerase δ–dependent DNA synthesis. Using two …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

DNA Holliday junction (HJ) is a four-way stranded DNA intermediate that formed in
replication fork regression, homology-dependent repair and mitosis, performing a significant …

The discovery of synthetic lethality as a result of the combined loss of PARP1 and BRCA has
revolutionized the treatment of DNA repair-deficient cancers. With the development of PARP …

Highlights•DNA damage tolerance (DDT) modes are temporally separated within the cell-
cycle.•DNA bending and cohesion facilitate recombination-mediated DDT during …