Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

That humans in endemic areas become immune to malaria offers encouragement to the
idea of developing protective vaccines. However natural immunity is relatively inefficient …

Background One of the criteria to objectively prioritize merozoite antigens for malaria
vaccine development is the demonstration that naturally acquired antibodies are associated …

Population Genetics and Microevolutionary Theory Explore the fundamentals of the
biological implications of population genetic theory In the newly revised Second Edition of …

Individuals living in areas where malaria is endemic are repeatedly exposed to many
different malaria parasite antigens. Studies on naturally acquired antibody-mediated …

The development of effective malaria vaccines may be hindered by extensive genetic
diversity in the surface proteins being employed as vaccine antigens. Understanding of the …

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …

Background Surrogate markers of protective immunity to malaria in humans are needed to
rationalize malaria vaccine discovery and development. In an effort to identify such markers …

Antibodies that bind to antigens expressed on the merozoite form of the malaria parasite can
inhibit parasite growth by preventing merozoite invasion of red blood cells. Inhibitory …

A pressing problem in studying the evolution of microbial pathogens is to determine the
extent to which these genomes recombine. This information is essential for locating …