TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …

Despite the revolution in recent decades regarding monoamine involvement in the
management of major depressive disorder (MDD), the biological mechanisms underlying …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Background Activity-dependent release of brain-derived neurotrophic factor (BDNF) in the
medial prefrontal cortex (mPFC) is essential for the rapid and sustained antidepressant …