mTOR in brain physiology and pathologies
J Bockaert, P Marin - Physiological reviews, 2015 - journals.physiology.org
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
Synaptic plasticity in depression: molecular, cellular and functional correlates
WN Marsden - Progress in Neuro-Psychopharmacology and …, 2013 - Elsevier
Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …
connectivity between neurons and neuronal circuits. This is achieved through changes to …
Zebrafish models in neuropsychopharmacology and CNS drug discovery
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …
Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine
S Deyama, K Kaneda - Neuropharmacology, 2023 - Elsevier
The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …
Glucocorticoids, genes and brain function
GR Juszczak, AM Stankiewicz - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …
review of microarray reports revealed 88 genes whose transcription is consistently regulated …
mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis
Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …
New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs
Despite the revolution in recent decades regarding monoamine involvement in the
management of major depressive disorder (MDD), the biological mechanisms underlying …
management of major depressive disorder (MDD), the biological mechanisms underlying …
Creatine, similar to ketamine, counteracts depressive-like behavior induced by corticosterone via PI3K/Akt/mTOR pathway
Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …
Neurotrophic and antidepressant actions of brain-derived neurotrophic factor require vascular endothelial growth factor
Background Activity-dependent release of brain-derived neurotrophic factor (BDNF) in the
medial prefrontal cortex (mPFC) is essential for the rapid and sustained antidepressant …
medial prefrontal cortex (mPFC) is essential for the rapid and sustained antidepressant …