Obesity is reaching epidemic proportions globally and represents a major cause of
comorbidities, mostly related to cardiovascular disease. The autonomic nervous system …

The adipocyte-derived hormone leptin is a peripheral signal that informs the brain about the
metabolic status of an organism. Although traditionally viewed as an appetite-suppressing …

Sprint interval training (SIT) and traditional endurance training elicit similar physiological
adaptations. From the perspective of metabolic function, superior glucose regulation is a …

Shift work causes circadian misalignment and is a risk factor for obesity. While some
characteristics of the human circadian system and energy metabolism differ between males …

The development of hypothalamic obesity (HO) following craniopharyngioma (CP) and other
suprasellar tumors leads to reduced patient quality of life. No treatment algorithms are …

Related US Application Data OTHER PUBLICATIONS (63) Continuation-in-part of
application No. 1 1/657,877 Accornero, Neri, et al., Selective Activation of Peripheral Nerve …

Context: A subset of patients diagnosed with idiopathic hypogonadotropic hypogonadism
(IHH) later achieves activation of their hypothalamic-pituitary-gonadal axis with …

Abstract 3′–5′-Cyclic adenosine monophosphate (cyclic AMP or cAMP) was first
described in 1957 as an intracellular second messenger mediating the effects of glucagon …

Patients with childhood-onset craniopharyngioma (CP) often suffer from obesity. We
evaluated two important etiological factors of obesity development, energy intake and …

Primary aging in adult humans is associated with a progressive, tonic activation of the
peripheral sympathetic nervous system (SNS). The purpose of this SNS activation and its …