[HTML][HTML] Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

A Dhiman, R Sharma, RK Singh - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

The potential mechanisms by which artemisinin and its derivatives induce ferroptosis in the treatment of cancer

Y Hu, N Guo, T Yang, J Yan… - Oxidative Medicine and …, 2022 - Wiley Online Library
Artemisinin (ART) is a bioactive molecule derived from the Chinese medicinal plant
Artemisia annua (Asteraceae). ART and artemisinin derivatives (ARTs) have been effectively …

Antiviral and immunomodulation effects of Artemisia

SG Kshirsagar, RV Rao - Medicina, 2021 - mdpi.com
Background and Objectives: Artemisia is one of the most widely distributed genera of the
family Astraceae with more than 500 diverse species growing mainly in the temperate zones …

GPX4 inhibition synergistically boosts mitochondria targeting nanoartemisinin-induced apoptosis/ferroptosis combination cancer therapy

H Yu, JM Li, K Deng, W Zhou, KH Li, CX Wang… - Biomaterials …, 2023 - pubs.rsc.org
Artemisinin, originally used for its antimalarial activity, has received much attention in recent
years for cancer therapy. The anticancer mechanisms of artemisinin are complicated and …

Artemisinin-type drugs for the treatment of hematological malignancies

RI Mancuso, MA Foglio, ST Olalla Saad - Cancer chemotherapy and …, 2021 - Springer
Qinghaosu, known as artemisinin (ARS), has been for over two millennia, one of the most
common herbs prescribed in traditional Chinese medicine (TCM). ARS was developed as …

Development of potential antitumor agents from the scaffolds of plant-derived terpenoid lactones

Y Ren, AD Kinghorn - Journal of medicinal chemistry, 2020 - ACS Publications
Naturally occurring terpenoid lactones and their synthetic derivatives have attracted
increasing interest for their promising antitumor activity and potential utilization in the …

Alleviating Catalyst Decay Enables Efficient Intermolecular C(sp3)–H Amination under Mechanochemical Conditions

X Lu, Y Bai, J Qin, N Wang, Y Wu… - … Sustainable Chemistry & …, 2021 - ACS Publications
The implementation of an energetically distinct mechanical activation strategy in catalysis
has unlocked exciting opportunities for sustainable organic synthesis. Differing from the …

Novel Bis-Artemisinin-Phloroglucinol hybrid molecules with dual anticancer and immunomodulatory Activities: Synthesis and evaluation

W Xu, X Zou, Y Zha, J Zhang, H Bian, Z Shen - Bioorganic Chemistry, 2023 - Elsevier
Abstract Bis-(10-deoxydihydroartemisinin)-phloroglucinol (9), has been synthesized in a one-
step reaction and has demonstrated strong inhibition to cancer cell proliferation and …

Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

JPL Ng, Y Han, LJ Yang, LM Birkholtz… - Frontiers in …, 2022 - frontiersin.org
Treatment of malaria with artemisinin combination therapies (ACTs) comprising artemisinin
or one of its clinical derivatives (Figure 1)(Cui and Su, 2009; Li et al., 2017) with a longer half …

[HTML][HTML] A knowledge graph of combined drug therapies using semantic predications from biomedical literature: Algorithm development

J Du, X Li - JMIR medical informatics, 2020 - medinform.jmir.org
Background: Combination therapy plays an important role in the effective treatment of
malignant neoplasms and precision medicine. Numerous clinical studies have been carried …