AMPK: a nutrient and energy sensor that maintains energy homeostasis
DG Hardie, FA Ross, SA Hawley - Nature reviews Molecular cell biology, 2012 - nature.com
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …
falling energy status, it promotes ATP production by increasing the activity or expression of …
Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity
JS Trimmer - Neuron, 2015 - cell.com
Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …
combinatorial assembly of a large number of principal and auxiliary subunits into an …
Multi-trait analysis for genome-wide association study of five psychiatric disorders
We conducted a cross-trait meta-analysis of genome-wide association study on
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …
Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy
R Minkeviciene, S Rheims, MB Dobszay… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However,
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …
The membrane electric field regulates the PIP2-binding site to gate the KCNQ1 channel
VS Mandala, R MacKinnon - Proceedings of the National …, 2023 - National Acad Sciences
Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …
The distribution and targeting of neuronal voltage-gated ion channels
HC Lai, LY Jan - Nature Reviews Neuroscience, 2006 - nature.com
Voltage-gated ion channels have to be at the right place in the right number to endow
individual neurons with their specific character. Their biophysical properties together with …
individual neurons with their specific character. Their biophysical properties together with …
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
The use of iPSC derived brain organoid models to study neurodegenerative disease has
been hampered by a lack of systems that accurately and expeditiously recapitulate …
been hampered by a lack of systems that accurately and expeditiously recapitulate …
Inactivation of the Kv2. 1 channel through electromechanical coupling
Abstract The Kv2. 1 voltage-activated potassium (Kv) channel is a prominent delayed-
rectifier Kv channel in the mammalian central nervous system, where its mechanisms of …
rectifier Kv channel in the mammalian central nervous system, where its mechanisms of …
A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.
JD Roderique, CS Josef, MJ Feldman, BD Spiess - Toxicology, 2015 - Elsevier
The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …
Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum–plasma membrane junctions in mammalian brain neurons
M Kirmiz, NC Vierra, S Palacio… - Journal of …, 2018 - Soc Neuroscience
Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …