AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …

We conducted a cross-trait meta-analysis of genome-wide association study on
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …

Alzheimer's disease is associated with an increased risk of unprovoked seizures. However,
the underlying mechanisms of seizure induction remain elusive. Here, we performed video …

Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …

Voltage-gated ion channels have to be at the right place in the right number to endow
individual neurons with their specific character. Their biophysical properties together with …

The use of iPSC derived brain organoid models to study neurodegenerative disease has
been hampered by a lack of systems that accurately and expeditiously recapitulate …

Abstract The Kv2. 1 voltage-activated potassium (Kv) channel is a prominent delayed-
rectifier Kv channel in the mammalian central nervous system, where its mechanisms of …

The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …

Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …